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Zymar Eye Drops |
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Zymar Structure
- 0.3% w/v - Gatifloxacin sesquihydrate equivalent;
- 0.01% w/v - Benzalkonium chloride US;
- Purified water I.P.
Zymar Indications
Zymar eye drops are indicated for the treatment of external bacterial infections of the eye.
Zymar Contraindications
Zymar eye drops are contraindicated in patients with a history of hypersensitivity to gatifloxacin, to other quinolones,
or to any of the components in Zymar eye drops.
Zymar and Pregnancy
There were no teratogenic effects observed in rats or rabbits following oral gatifloxacin doses up to 50 mg/kg/day
(approximately 1000-fold higher than the maximum recommended ophthalmic dose). However, skeletal/craniofacial
malformations or delayed ossification, atrial enlargement, and reduced fetal weight were observed in
fetuses from rats given >150 mg/kg/day (approximately 3000-
fold higher than the maximum recommended ophthalmic
dose). In a perinatal/postnatal study, increased late postimplantation
loss and neonatal/perinatal mortalities were
observed at 200 mg/kg/day (approximately 4500 times the
maximum recommended ophthalmic dose). Because there are
no adequate and well-controlled studies in pregnant women,
Zymar eye drop should be used during pregnancy only if
the potential benefit justifies the potential risk to the fetus.
Zymar and Nursing Mothers
Zymar eye drops are excreted in the breast milk of rats. Zymar eye drop is not known whether Zymar eye drop is excreted in
human milk. Because many drugs are excreted in human milk,
caution should be exercised when gatifloxacin is administered to a nursing woman.
Zymar Side Effects
The most frequently reported adverse events in the overall study population were:
- Papillary conjunctivitis;
- Keratitis;
- Increased lacrimation;
- Conjunctival irritation;
These events occurred in approximately 5-10% of patients.
Other reported reactions occurring in 1-4% of patients were:
- Taste disturbance;
- Reduced visual acuity;
- Red eye;
- Headache;
- Eyelid edema;
- Eye pain;
- Eye irritation;
- Eye discharge;
- Dry eye;
- Conjunctival hemorrhage;
- Chemosis;
Zymar Dosage
Zymar eye drops recommended dosage regimen for the treatment of bacterial conjunctivitis is:
Days 1 - 2: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times daily.
Days 3 - 7: Instill one drop up to four times daily while awake.
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Ciplox