Eye drops


Zymar

Where to buy Zymar ?

Structure

- 0.3% w/v - Gatifloxacin sesquihydrate equivalent;
- 0.01% w/v - Benzalkonium chloride US;
- Purified water I.P.

Indications

Zymar eye drops are indicated for the treatment of external bacterial infections of the eye.

Contraindications

Zymar eye drops are contraindicated in patients with a history of hypersensitivity to gatifloxacin, to other quinolones, or to any of the components in Zymar eye drops.

Pregnancy

There were no teratogenic effects observed in rats or rabbits following oral gatifloxacin doses up to 50 mg/kg/day (approximately 1000-fold higher than the maximum recommended ophthalmic dose). However, skeletal/craniofacial malformations or delayed ossification, atrial enlargement, and reduced fetal weight were observed in fetuses from rats given >150 mg/kg/day (approximately 3000- fold higher than the maximum recommended ophthalmic dose). In a perinatal/postnatal study, increased late postimplantation loss and neonatal/perinatal mortalities were observed at 200 mg/kg/day (approximately 4500 times the maximum recommended ophthalmic dose). Because there are no adequate and well-controlled studies in pregnant women, Zymar eye drop should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Nursing Mothers

Zymar eye drops are excreted in the breast milk of rats. Zymar eye drop is not known whether Zymar eye drop is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when gatifloxacin is administered to a nursing woman.

Side Effects

The most frequently reported adverse events in the overall study population were:
- Papillary conjunctivitis;
- Keratitis;
- Increased lacrimation;
- Conjunctival irritation;

These events occurred in approximately 5-10% of patients.

Other reported reactions occurring in 1-4% of patients were:
- Taste disturbance;
- Reduced visual acuity;
- Red eye;
- Headache;
- Eyelid edema;
- Eye pain;
- Eye irritation;
- Eye discharge;
- Dry eye;
- Conjunctival hemorrhage;
- Chemosis;

Dosage

Zymar eye drops recommended dosage regimen for the treatment of bacterial conjunctivitis is:
Days 1 - 2: Instill one drop every two hours in the affected eye(s) while awake, up to 8 times daily.
Days 3 - 7: Instill one drop up to four times daily while awake.

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