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Tobrex Eye Drops |
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Tobrex Structure
- 3mg - Tobramycin sulphate USP;
- 0.04mg Benzalkonium Chloride USP;
Tobrex Indications
Tobrex eye drops are a topical antibiotic formulation indicated in the treatment of external infections
of the eye and its adnexa caused by susceptible bacteria. Appropriate monitoring of bacterial response to topical antibiotic
therapy should accompany the use of Tobrex eye drops.
Tobrex Contraindications
Tobrex eye drops are contraindicated in patients with known hypersensitivity to any ingredient in the
drug.
Tobrex and Pregnancy
Reproduction studies in animals using Tobrex eye drops doses up to 33 times the normal
human systemic dose have not revealed evidence of impaired fertility or harn to foetus. There are, however, no control studies
to date using Tobrex eye drops in pregnant women and Tobrex eye drops should be used during pregnancy only when clearly needed.
Tobrex and Nursing Mothers
Because of the potential for serious adverse reactions from the drug in nursing infants, Tobrex eye drops should not
normally be used in nursing women.
A decision should be made whether to discontinue nursing or
discontinue Tobrex eye drops, taking into account the importance of
the medicine to the mother.
Tobrex Side Effects
Tobrex eye drops appears to have low order of toxicity when applied topically to the eye. However,
sensitisation to Tobrex eye drops may occasionally result from topical application. If a sensitive reaction occurs during
Tobrex eye drop therapy, the drop should be discontinued. The most frequent adverse reactions to Tobrex eye drops are:
- Conjunctival erythema;
- Eyelid;
- Hypersensitivity;
- Increased lacrimation;
- Itching and edema;
- Localized ocular toxicity;
These reactions occur in less than 3% of patients receiving Tobrex eye drops and
usually disappear when the drop is discontinued. Punctate keratitis has also been reported following excessive application
of Tobrex.
Tobrex Dosage
For mild to moderate infections, 1 or 2 drops of Tobrex eye drop should be instilled into the infected eye(s) every
4 hours. In severe infections, including Pseudomonas aeruginosa infections, 2 drops of the solution should be instilled into
the infected eye(s) every hour initially. When improvement occurs, frequency of application can be decreased. Therapy should be
continued for at least 48 hours after the infection has been controlled.
Tobrex Overdosage
Clinically apparent signs and symptoms of an overdose of
Tobrex eye drop may be similar to adverse reactions seen in some patients:
- Edema;
- Erythema;
- Increased lacrimation;
- Lid itching;
- Punctate keratitis;
Tobrex Form
Tobrex eye drops are available in 5 ml plastic dropper bottles.
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