Eye drops


Azopt

Where to buy Azopt ?

Structure

- 1% - Brinzolamide ophthalmic suspension;

Indications

Azopt eye drops 1% are indicated in the treatment of elevated intraocular pressure in patients with ocular hypertension or open-angle glaucoma.

Contraindications

Azopt eye drops 1% are contraindicated in patients who are hypersensitive to any component of Azopt eye drops.

Pregnancy

Teratogenic Effects: Pregnancy Category C. Developmental toxicity studies with brinzolamide in rabbits at oral doses of 1, 3, and 6 mg/kg/day (20, 62, and 125 times the recommended human ophthalmic dose) produced maternal toxicity at 6 mg/kg/day and a significant increase in the number of fetal variations, such as accessory skull bones, which was only slightly higher than the historic value at 1 and 6 mg/kg. In rats, statistically decreased body weights of fetuses from dams receiving oral doses of 18 mg/kg/day (375 times the recommended human ophthalmic dose) during gestation were proportional to the reduced maternal weight gain, with no statistically significant effects on organ or tissue development. Increases in unossified sternebrae, reduced ossification of the skull, and unossified hyoid that occurred at 6 and 18 mg/kg were not statistically significant. No treatment-related malformations were seen. Following oral administration of 14C-brinzolamide to pregnant rats, radioactivity was found to cross the placenta and was present in the fetal tissues and blood.

Nursing Mothers

In a study of Azopt eye drops in lactating rats, decreases in body weight gain in offspring at an oral dose of 15 mg/kg/day (312 times the recommended human ophthalmic dose) were seen during lactation. No other effects were observed. However, following oral administration of 14C-brinzolamide to lactating rats, radioactivity was found in milk at concentrations below those in the blood and plasma.

Side Effects

In clinical studies of Azopt eye drops 1%, the most frequently reported adverse events associated with Azopt eye drops 1% were:
- Unusual taste;
- Sour;
- Blurred vision;
- Bitter;

These events occurred in approximately 5-10% of patients:
- Rhinitis;
- Ocular pruritus;
- Ocular pain;
- Ocular keratitis;
- Ocular discomfort;
- Ocular discharge;
- Hyperemia;
- Headache;
- Foreign body sensation;
- Dry eye;
- Dermatitis;
- Blepharitis;

The following adverse reactions were reported at an incidence below 1%:
- Urticaria;
- Tearing;
- Sticky sensation;
- Pharyngitis;
- Nausea;
- Lid margin crusting;
- Kidney pain;
- Keratopathy;
- Keratoconjunctivitis;
- Hypertonia;
- Eye fatigue;
- Dyspnea;
- Dyspepsia;
- Dry mouth;
- Dizziness;
- Diplopia;
- Diarrhea;
- Conjunctivitis;
- Chest pain;
- Alopecia;
- Allergic reactions;

Overdosage

Although no human data are available, electrolyte imbalance, development of an acidotic state, and possible nervous system effects may occur following oral administration of an overdose. Serum electrolyte levels (particularly potassium) and blood pH levels should be monitored.

Dosage

Azopt eye drops recommended dose are 1 drop of Azopt eye drops 1% in the affected eye(s) 3 times daily. Azopt eye drops 1% may be prescribed concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being prescribed, the drugs should be administered at least ten minutes apart.

Form

Azopt eye drops 1% is supplied in plastic dispensers with a controlled dispensing-tip as follows:
- 5mL;
- 10 mL;
- 15 mL;

Antibiotics
Brulamycin
Ciloxan
Ciplox
Cipmox
Garamycin
Maxitrol
Ocuflox
Sofracort
Soframycin
Tobrex
Vigamox
Zymar
Antihistamine
Alergoftal
Allergo Comod
Cromolux
Ketotifen
Livostin
Opatanol
Patanol
Zaditor
Corticosteroids
Flomex
FML
Fluorometholone
Loteflam
Pred Forte
Decongestants
Albalon
Glaucoma
Allergan
Alphagan
Azopt
Azoptic
Betagan
Betaxolol
Betoptic
Bimatoprost
Brimodin P
Brimonidine
Combigan
Cosopt
Dorzolamide
Dorzox
Isopto
Latim
Lumigan
Pilagan
Pilopt
Phospholine Iodide
Timolol
Timoptic
Timpilo
Travatan
Trusopt
Xalacom
Xalatan
Mast cell stabilizers
Crolom
Cromal
Epina
NSAID
Acular
Acularen
Cyclosporine
Sodium Sulamyd
Others
Adsorbonac
Celluvisc
Cyclogyl
Epinastine
Flur
Flarex
Glaucoprost
Iobrim
Iotim
Methopt
Mydriacyl
Oxyal
Propine
Restasis
Tears
Tropicamide
Vistil


EyeDropsInfo.com © 2009 - 2012