Eye drops


Alphagan

Where to buy Alphagan ?

Structure

- Benzalkonium chloride 0.05 mg;
- Brimonidine tartrate 2 mg;

Indications

Alphagan eye drops are indicated for lowering intraocular pressure in patients with:
- ocular hypertension;
- open-angle glaucoma.
The IOP lowering effect of these eye drops diminishes over time in some patents. This loss of effect appears with a variable time of onset in each patient and should be closely monitored.

Contraindications

Alphagan eye drops are contraindicated in patients with hypersensitivity to brimonidine tartrate or any component of this medication. Alphagan eye drops are contraindicated in patients receiving monoamine oxidase (MAO) inhibitor therapy.

Pregnancy

Reproduction studies performed in rats with oral doses of 0.66mg base/kg revealed no evidence of impaired fertility or harmed foetus due to eye drops. Dosing of this level produced 100 times the plasma Alphagan eye drops concentration level seen in humans following multiple ophthalmic doses. There are no studies of eye drops in pregnant women, however, in animal studies brimonidine crossed the placenta and entered into the foetal circulation to a limited extent. Eye drops should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the foetus.

Nursing Mothers

Alphagan eye drops are not known whether these drops are excreted in human milk, although in animal studies, brimonidine tartrate has been shown to be excreted in breast milk. A decision should be made whether to discontinue nursing or to discontinue the drug. taking into account the importance of the drug to the mother.

Side Effects

Side effects occurring in approximately 10 - 30% of the subjects, in descending order of incidence, included:
- Blurring;
- Burning and stinging;
- Conjunctival follicles;
- Fatigue/drowsiness;
- Foreign body sensation;
- Headache;
- Ocular allergic reactions;
- Ocular hyperemia;
- Ocular pruritis;
- Oral dryness;

Effects occurring in 3-9% of the subjects in descending order included:
- Abnormal vision;
- Asthenia;
- Blepharitis;
- Conjunctival blanching;
- Conjunctival edema;
- Corneal staining/erosion;
- Dizziness;
- Eyelid edema;
- Eyelid erythema;
- Gastro intestinal symptoms;
- Muscular pain;
- Ocular ache/pain;
- Ocular dryness;
- Ocular irritation;
- Photophobia;
- Tearing;
- Upper respiratory symptoms;

The following side effects were reported in less than 3% of the patients:
- Abnormal taste;
- Anxiety;
- Conjunctival discharge;
- Conjunctival hemorrhage;
- Depression;
- Hypertension;
- Insomnia;
- Lid crusting;
- Nasal dryness;
- Palpitations;
- Syncope;

Overdosage

No information is available on Alphagan eye drops overdosage in humans.

Dosage

Alphagan recommended dose is 1 drop inthe affected eye(s) 2 times per day.

Form

Alphagan ophthalmic solution is supplied as 0.2% Sterile Solution in 5 ml white opaque plastic dropper bottles.

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